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Grammatica Tedesca Per Principianti Download File PDF Grammatica Per Principianti Grammatica Per PrincipiantiThe influence of alpha-tocopherol succinate on the infarct size and neurological deficit after transient focal cerebral ischaemia in rat.
The present study was undertaken to evaluate the efficacy of alpha-tocopherol succinate (vitamin E) administered immediately after middle cerebral artery (MCA) occlusion on the volume of tissue damaged and neurological deficit in rats. Vascular occlusion was induced by an intraluminal filament in the right MCA for 60 min and then reperfusion allowed for a further 24 h. Rats were randomized to a sham group, a vehicle-treated control group (deionized water), or a vitamin E-treated group (intraperitoneal injection of alpha-tocopherol succinate (80 mg/kg) every 12 h, starting immediately after the surgery). The cortical infarct volume was examined by measuring the volume of Nissl-stained infarcts on brain sections stained by cresyl violet. Neurological deficits were evaluated by the neurological deficit score. Vitamin E administration reduced cortical infarct volume in a dose-dependent manner compared with controls. The infarct size was significantly smaller in both the 20 and 80 mg/kg groups than the vehicle group, with values of 46.5+/-4.1 and 39.0+/-5.8%, respectively. The neurological deficit score was significantly lower in the 20 and 80 mg/kg groups than controls. Thus, treatment with alpha-tocopherol succinate significantly reduced the cortical infarct volume and neurological deficit in rats that underwent transient focal cerebral ischaemia.The present invention relates to a method for making iron-oxide bearing mixture.
Iron bearing mixture, the particles of which can be oxidized, react with oxygen in air during storage and processing and form water. In view of the unfavorable water-splitting behaviour of iron and the water formed 0b46394aab