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Free download 3 sisters lara jade aude advisoryr part 3 maxspeed. We are the people you call when no one else can make what you want!Elucidation of the role of an interferon in the protection of mice from Rift Valley fever infection.
The role of interferon in the protection of mice from Rift Valley fever (RVF) virus was investigated. Female, ICR mice were injected intramuscularly with either human interferon gamma (HuIFN-gamma), mouse interferon gamma (MuIFN-gamma), MuIFN-gamma attached to polystyrene (PS), or interleukin-2 (IL-2). The mice were then infected with RVF virus and the survival rate was monitored. It was found that only mice treated with MuIFN-gamma attached to PS survived. Further, those treated with both MuIFN-gamma and PS as well as IL-2 survived. In a competitive assay between the viral antigen and anti-RVF IgM monoclonal antibody, only anti-RVF IgM antibody was able to protect mice from RVF virus. However, this protection was found only in mice treated with MuIFN-gamma. The neutralization of RVF virus by anti-RVF IgG antibody was not observed. It was suggested that the protection mediated by anti-RVF IgM monoclonal antibody was dependent on the presence of MuIFN-gamma.